CREB1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 1:500 - 1:1000
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	A phospho specific peptide corresponding to residues surrounding S133 of human CREB1
Formulation	Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	341
Gene Name	cAMP responsive element binding protein 1
Database Link	NP_004370 Entrez Gene 12912 MouseEntrez Gene 81646 RatEntrez Gene 1385 Human UniProt ID P16220
Background	CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories .
Synonyms	CREB
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer

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