Caspase-7 (CASP7) Mouse Monoclonal Antibody [Clone ID: 25B881.1]

Specifications

Product Data
Clone Name	25B881.1
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry, Western Blot: 1-2 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was generated against recombinant protein of active form of human Caspase-7.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 7
Database Link	NP_203124 Entrez Gene 12369 MouseEntrez Gene 64026 RatEntrez Gene 840 Human UniProt ID P55210
Background	Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-7 is derived from the cleavage of proMCH3-alpha into 2 subunits, p20 and p12 by Caspase-3. Sequence analysis revealed that the MCH3-alpha amino acid sequence had the highest homology to caspase-3 (53% identity) and less than 37% identity with all other family members.
Synonyms	CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Alzheimer's disease, Apoptosis

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