TLR6 Mouse Monoclonal Antibody [Clone ID: 86B1153.2]

Specifications

Product Data
Clone Name	86B1153.2
Applications	FC, IHC, WB
Recommend Dilution	Immunohistochemistry-Paraffin: 5 ug/ml, Immunohistochemistry: 1:10-1:500, Flow Cytometry: 3 ug/10-6 cells, Flow (Intracellular), Flow (Cell Surface), Western Blot
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was developed against a synthetic peptide corresponding to amino acids 408-424 of human TRL6.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	toll like receptor 6
Database Link	NP_006059 Entrez Gene 10333 Human UniProt ID Q9Y2C9
Background	The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69% identity at the amino acid level. Human TLR6 consists of a predicted 807 amino acids with a molecular weight of approximately 92 kDa. Human and mouse TLR6 share an amino acid identity of 73%. TLR6 activates both NF-kB and c-Jun N-terminal Kinase (JNK). The amino acids in the cytoplasmic domain of IL-1 receptor, which are critical for NF-kB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6. TLR6 is predominantly expressed in spleen, thymus, ovary, and lung.
Synonyms	CD286
Note	Immunohistochemistry-Paraffin and Flow cytometry/(Intracellular)
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Toll-like receptor signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.