Livin (BIRC7) Mouse Monoclonal Antibody [Clone ID: 88C570]

Specifications

Product Data
Clone Name	88C570
Applications	ICC/IF, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 2-5 ug/ml, Western Blot: 1-2 ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human livin protein was used as immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	baculoviral IAP repeat containing 7
Database Link	NP_647478 Entrez Gene 79444 Human UniProt ID Q96CA5
Background	The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, Kasof and Gomes (1), Vucic et al. and Ashhab et al. have identified a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells.
Synonyms	KIAP; LIVIN; ML-IAP; MLIAP; RNF50
Note	Immunocytochemistry/Immunofluorescence see Nachmias et al, 2007
Reference Data
Protein Families	Druggable Genome

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