D4 (ARHGDIB) Mouse Monoclonal Antibody [Clone ID: 10D774]

CAT#: TA336402

Mouse Monoclonal D4-GDI/RhoGDI2 Antibody (10D774)



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CNY 5,381.00


货期*
5周

规格
    • 100 ug

Cited in 1 publication.

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Specifications

Product Data
Clone Name 10D774
Applications FC, ICC/IF, WB
Recommend Dilution Immunocytochemistry/ Immunofluorescence, Flow Cytometry, Western Blot: 1-2 ug/ml
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to human D4-GDI/RhoGDI2 was used as the immunogen.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name Rho GDP dissociation inhibitor beta
Background D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.
Synonyms D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1; RhoGDI2
Reference Data
Protein Families Druggable Genome
Protein Pathways Neurotrophin signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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