TLR7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC
Recommend Dilution	Flow Cytometry, Flow (Intracellular): 0.5 - 2 ug/1x10^6 cells, Immunohistochemistry: 1:10 - 1:500, Immunohistochemistry-Paraffin: 1:10 - 1:50, Flow (Cell Surface), Immunohistochemistry-Frozen: 1:20
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of amino acids 684-701 of human TLR7 (NP_057646).
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	toll like receptor 7
Database Link	NP_057646 Entrez Gene 170743 MouseEntrez Gene 51284 Human UniProt ID Q9NYK1
Background	The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response.
Synonyms	TLR7-like
Note	Flow Cytometry: (Cell Surface): see Wong et al, 2007 for details Immunohistochemistry-Frozen: (1:20) (see product citation, Chen et al., 2005)
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Toll-like receptor signaling pathway

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