Prion protein PrP (PRNP) Rabbit Polyclonal Antibody

CAT#: TA336429

Rabbit Polyclonal Prion protein Antibody



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CNY 4,897.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 0.5-2 ug/ml
Reactivity Bovine, Sheep
Host Rabbit
Clonality Polyclonal
Immunogen Amino acids 142-148 of BSE protein were used as the immunogen.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name prion protein
Background BSE, also known as prion protein, is a membrane glycosylphosphatidylinositol-anchored glycoprotein belonging to the prion family of proteins and is responsible for several transmissible neurodegenerative spongiform encephalopathies. Though the exact function of BSE is not clear, reports suggest that it has a tendency to aggregate forming polymers known as rods and might act as a signaling neurotransmitter. BSE acts as a potent anti-apoptotic protein against BAX-mediated cell-death. Expression is higher in the brain of humans and animals infected with several degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy (TME). Aberration in this protein is also associated with fatal familial insomnia and Huntington disease-like 1.
Synonyms AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc
Reference Data
Protein Families ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
Protein Pathways Prion diseases
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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