Prion protein PrP (PRNP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 0.5-2 ug/ml
Reactivity	Bovine, Sheep
Host	Rabbit
Clonality	Polyclonal
Immunogen	Amino acids 217-229 of BSE protein were used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	prion protein
Database Link	NP_898902 Entrez Gene 5621 Human UniProt ID F7VJQ1
Background	BSE, also known as prion protein, is a membrane glycosylphosphatidylinositol-anchored glycoprotein belonging to the prion family of proteins and is responsible for several transmissible neurodegenerative spongiform encephalopathies. Though the exact function of BSE is not clear, reports suggest that it has a tendency to aggregate forming polymers known as rods and might act as a signaling neurotransmitter. BSE acts as a potent anti-apoptotic protein against BAX-mediated cell-death. Expression is higher in the brain of humans and animals infected with several degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy (TME). Aberration in this protein is also associated with fatal familial insomnia and Huntington disease-like 1.
Synonyms	AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc
Reference Data
Protein Families	ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
Protein Pathways	Prion diseases

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