DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: 32A1380]

CAT#: TA336474

Mouse Monoclonal TRAIL R1/TNFRSF10A Antibody (32A1380)



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CNY 5,381.00


货期*
5周

规格
    • 100 ug

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经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
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Specifications

Product Data
Clone Name 32A1380
Applications CyTOF-ready, FC, ICC/IF, WB
Recommend Dilution Western Blot: 2-4 ug/ml, Simple Western: 20 ug/ml, Immunocytochemistry/ Immunofluorescence, Flow (Cell Surface), Flow (Intracellular), Flow Cytometry: 1:20-1:2000, CyTOF-ready
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen This monoclonal antibody was raised against a peptide corresponding to amino acid 2 to 21 of human DR4.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name tumor necrosis factor receptor superfamily member 10a
Background Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
Synonyms APO2; CD261; DR4; TRAILR-1; TRAILR1
Note A 57 kDa band should be observed. This antibody is routinely tested be western blot analysis. For other applicatons, please refer to appropriate published references for more information.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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