FOXP1 Mouse Monoclonal Antibody [Clone ID: JC12]

Specifications

Product Data
Clone Name	JC12
Applications	CyTOF-ready, FC, ICC/IF, IHC, IP, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin: 1:200-1:500, Immunohistochemistry-Frozen: 1:10-1:500, Flow Cytometry: 1 ug per million cells, Immunohistochemistry: 1:10-1:500, Western Blot: 2ug/ml, CyTOF-ready
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Human FOXP1 [Uniprot# Q9H334]
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	forkhead box P1
Database Link	NP_116071 Entrez Gene 108655 MouseEntrez Gene 27086 Human UniProt ID Q9H334
Background	FOXP1 is a member of the Forkhead Box Protein family. These proteins are transcription factors that are characterised by a highly conserved forkhead DNA-binding domain. FOXP1 is a repressor of transcription. It forms homodimers, and also heterodimerises with FOXP2 and FOXP4, to facilitate its binding to DNA for transcriptional regulation. A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukaemia, and FOXP1 is also implicated in mental retardation with language impairment and autistic features (MRLIAF). Chromosomal translocation of FOXP1 is implicated in mucosa-associated lymphoid tissue (MALT) lymphoma.
Synonyms	12CC4; hFKH1B; HSPC215; MFH; QRF1
Note	Heat induced antigen retrieval with Sodium Citrate buffer pH 6.0 is recommended when using this antibody for IHC-P.
Reference Data
Protein Families	Transcription Factors

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