TMP21 (TMED10) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry: 1:100-1:200, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 1:100-1:200, Knockdown Validated
Reactivity	Human, Mouse, Rat, Bovine, Chicken, Primate, Rabbit
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an internal sequence of the human TMP21 protein (within residues 100-200). [Swiss-Prot# P49755]
Formulation	PBS, 30% glycerol, 0.1% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	21 kDa
Gene Name	transmembrane p24 trafficking protein 10
Database Link	NP_006818 Entrez Gene 68581 MouseEntrez Gene 84599 RatEntrez Gene 10972 Human UniProt ID P49755
Background	TMP21 (transmembrane protein Tmp21) is a type I transmembrane protein with large luminal domain belonging to p24 endoplasmic reticulum/Golgi cargo family and play key roles in protein transport, membrane structure organization and secretory pathway. TMP21 is ubiquitously expressed with highest protein levels observed in pancreas and intestines. In addition to its well established role in vesicle formation and cargo transport in ER/Golgi, TMP21 has been implicated in recruitment of small GTPase ADP-ribosylation factor 1 to Golgi apparatus and ADP-ribosylation factor 1-dependent assembly of actin in the Golgi. TMP21 forms a component of presenilin complex at the plasma membranes and modulates gamma -secretase cleavage. The cytoplasmic tails of p24 family interacts with coatomer (major component of coat protein complex I or COP-I), to facilitate transport between ER and Golgi. TMP21 cycles through the early secretory pathway between intermediate and cis-Golgi compartments, and is essential for proper organization of the Golgi apparatus. TMP21 also plays an essential and non-redundant role in earliest stages of mammalian development.
Synonyms	p23; P24(DELTA); p24d1; S31I125; S31III125; Tmp-21-I; TMP21
Note	This TMP21 antibody is useful for Immunohistochemistry-Paraffin and Western blot analysis where a band is seen at ~21 kDa.
Reference Data
Protein Families	Transmembrane

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