Neurofibromin (NF1) Rabbit Polyclonal Antibody

CAT#: TA336613

Rabbit Polyclonal Neurofibromin 1 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 500 ul

Product images

经常一起买 (2)
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Specifications

Product Data
Applications ICC/IF, IHC, WB
Recommend Dilution Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin: 1:200-1:500, Immunohistochemistry-Frozen: 1:200-1:500, Immunohistochemistry: 1:200-1:500, Western Blot: 1:500-1:2000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen An N-terminal peptide of Neurofibromin 1 (within amino acids 1-50). [UniProt# P21359]
Formulation Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Whole antisera
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name neurofibromin 1
Background Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).
Synonyms NFNS; VRNF; WSS
Note This Neurofibromin 1 antibody can be used for Western blot and Immunohistochemistry of frozen and paraffin-embedded sections. In WB, a band-set at 220-240 kDa and a higher MW band at 450 kDa (uncharacterized) can be seen. For IHC, antigen retrieval is not required for immunostaining of frozen sections. Antigen retrieval with trypsin or citrate improves immunostaining of paraffin sections. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 23910086)
Reference Data
Protein Families Druggable Genome
Protein Pathways MAPK signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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