FANCC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IP, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Western Blot: 1:500-1:1000, Immunoprecipitation: 1:10-1:500
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal human FANCC fusion protein [Swiss-Prot #Q00597].
Formulation	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	63 kDa
Gene Name	Fanconi anemia complementation group C
Database Link	NP_000127 Entrez Gene 2176 Human UniProt ID Q00597
Background	FANCC (Fanconi anemia group C protein) is a DNA repair protein which implicates in post-replication DNA repair or a cell cycle checkpoint function. FANCC also involves in the interstrand DNA cross-link repair as well as the maintenance of chromosome stability/integrity. FANCC participates in the multisubunit FA complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM and HSP70) which is not found in FA patients. Upon IFNG induction, FANCC facilitate STAT1 activation via recruitement of STAT1 to IFNGR1. FANCC interacts with ZBTB32 (upon IFNG induction), CDK1, STAT1 etc and FANCC-EIF2AK2 interactions leads to augmented EIF2AK2 activation and cell death. FANCC is expressed ubiquitously and the major form is nuclear while the minor form is cytoplasmic. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC), disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.
Synonyms	FA3; FAC; FACC
Note	This FANCC antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western blot where a band is seen ~63 kDa.
Reference Data
Protein Families	Druggable Genome

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