p75 NGF Receptor (NGFR) Mouse Monoclonal Antibody [Clone ID: 2F1C2]

Specifications

Product Data
Clone Name	2F1C2
Applications	ELISA, FC, ICC/IF, WB
Recommend Dilution	ELISA: 1:10000, Western Blot: 1:500 - 1:2000, Flow Cytometry: 1:200 - 1:400, Immunocytochemistry/ Immunofluorescence: 1:200 - 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human p75NTR/NGF Receptor expressed in E. coli. [UniProt# P08138]
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	45 kDa
Gene Name	nerve growth factor receptor
Database Link	NP_002498 Entrez Gene 4804 Human UniProt ID P08138
Background	p75NTR/NGF Receptor, also known as Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. p75NTR/NGF Receptor plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of p75NTR/NGF Receptor by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to p75NTR/NGF Receptor activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).
Synonyms	CD271; Gp80-LNGFR; p75(NTR); p75NTR; TNFRSF16
Note	This p75NTR/NGF Receptor (2F1C2) antibody is useful in Western Blot, ELISA, Immunocytochemistry/Immunofluorescence and Flow Cytometry.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Neurotrophin signaling pathway

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