Stathmin 1 (STMN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC/IF, IHC, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence, Knockout Validated, Immunohistochemistry: 1:100 - 1:250, Western Blot: 0.5-1 ug/ml, Immunohistochemistry-Paraffin: 1:100 - 1:250, ELISA: 1:100-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an C-terminal portion of the human Stathmin 1 protein (between residues 100-149) [UniProt P16949]
Formulation	PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	17 kDa
Gene Name	stathmin 1
Database Link	NP_981944 Entrez Gene 16765 MouseEntrez Gene 29332 RatEntrez Gene 3925 Human UniProt ID P16949
Background	Stathmin 1 (STMN1), also known as leukemia-associated phosphoprotein p18, metablastin, oncoprotein 18 (op18), phosphoprotein p19, prosolin, protein Pr22, and pp17, is a member of the stathmin family that encodes a ubiquitous cytosolic phosphoprotein that functions as an intracellular relay for regulatory signals of the cellular environment. STMN1 is involved in the regulation of the microtubule filament system by destabilizing microtubules. In addition, STMN1 has resently been implicated as a potential target of the ASK1-p38 MAP kinase cascade. Phosphorylation at STMN1 Ser-16 may be required for axon formation during neurogenesis. The STMN1 gene has been linked to the control of the learned and innate fear responses. STMN1 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma; suggesting that STMN1 may be an ideal target for anti-cancer therapeutics.
Synonyms	C1orf215; Lag; LAP18; OP18; PP17; PP19; PR22; SMN
Reference Data
Protein Pathways	MAPK signaling pathway

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