CX3CR1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC/IF, IHC
Recommend Dilution	ELISA: 1:100-1:2000, Immunohistochemistry: 1:10-1:500, Immunohistochemistry-Paraffin: 2 ug/ml, Immunocytochemistry/ Immunofluorescence: 10ug/mL, Immunohistochemistry-Frozen
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Antibody was raised against a peptide corresponding to amino acids 2 to 21 of human CX3CR1. The sequence differs from those of mouse and rat CX3CR1 by four amino acids (NP_001328).
Formulation	PBS with 30% Glycerol, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	C-X3-C motif chemokine receptor 1
Database Link	NP_001328 Entrez Gene 13051 MouseEntrez Gene 171056 RatEntrez Gene 1524 Human UniProt ID P49238
Background	CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.
Synonyms	CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28
Note	In Western blots, ~50 kDa band can be detected. Immunocytochemistry/Immunofluorescence was reported in scientific literature.
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction

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