SUV420h1 (KMT5B) Rabbit Polyclonal Antibody

CAT#: TA336868

Rabbit Polyclonal SUV420h1 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

Product images

经常一起买 (2)
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Transient overexpression lysate of suppressor of variegation 4-20 homolog 1 (Drosophila) (SUV420H1), transcript variant 2
    • 100 ug

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Specifications

Product Data
Applications ICC/IF, IHC, WB
Recommend Dilution Immunohistochemistry: 1:200, Immunocytochemistry/ Immunofluorescence: 1:100-1:300, Immunohistochemistry-Paraffin: 1:200, Western Blot (Negative)
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to an internal portion of the human SUV420h1 protein (between residues 100-150) [UniProt Q4FZB7]
Formulation PBS with 30% Glycerol, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name lysine methyltransferase 5B
Background SUV420H1 (Histone-lysine N-methyltransferase 5B, KMT5B) is a histone methyltransferase that specifically di- and trimethlyates lysine 20 of H4 (H4 K20Me3), an epigenetic mark of transcriptional repression. This mark, along with trimethylation of histone 3 lysine 9 (H3 K9me3) and monomethylation of H3 lysine 27 (H3 K27me1), define genomic regions of constitutive heterochromatin that are poor in activated genes. This enzyme is essential for development, with Suv420h1 knockout mice proving lethal perinatally and showing overall growth retardation. The RB1 family of proteins have been shown to interact with, and target, KMT5B to histones, enabling the enzyme to function.
Synonyms CGI-85; CGI85; SUV420H1
Note This SUV420h1 antibody is useful for Immunocytochemistry/Immunofluorescence and IHC-paraffin embedded sections. In ICC/IF, nuclear staining was observed in A431 cells. In IHC-P, staining was observed in the nucleus of mouse epidermis tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. This antibody is not recommended for Western Blot.
Reference Data
Protein Families Druggable Genome
Protein Pathways Lysine degradation
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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