HDAC7A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 0.1-0.5 ug/ml
Reactivity	Human, Rat, Bovine, Canine, Equine, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	Within the range of amino acids 443-460 of human HDAC-7 protein were used as the immunogen ('b' represents a phosphorylated serine at position 448).
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Peptide affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Database Link	Entrez Gene 84582 Rat
Background	Histone deacetylase 7 is a thymus-specific, intracellular transcription factor belonging to the class IIa histone deacetylase family. Reports suggest that dephosphorylation and nuclear localization of HDAC-7 is promoted by Myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+CD8+ double-positive thymocytes. HDAC-7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
Synonyms	DKFZP586J0917; HDAC7
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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