CD161 (KLRB1) Mouse Monoclonal Antibody [Clone ID: 14F1F11]

Specifications

Product Data
Clone Name	14F1F11
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry-Paraffin: 5 ug/ml, Immunohistochemistry, Western Blot: 1-5 ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Amino acids 68-225 of human CD161 were used as the immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	killer cell lectin like receptor B1
Database Link	NP_002249 Entrez Gene 3820 Human UniProt ID Q12918
Background	CD161 is a C-Type Lectin Receptor, also known as NKR-P1A, previously found on NKT cells and subsets of T-cells. Phenotyping of cells that are functionally producing IL-17 has shown the one constant marker is CD161. While it had been shown previously that human CD4+ cells that produce both IL-17 and IFNg give rise to Th17/Th1 cells, indicating common etiology of these two T cell subsets, a clear marker for cells producing IL-17 is CD161. In fact, all cells characterized as the following subsets CD4+TCRab+, CD8+TCRab+, CD4-CD8-TCRab+, and CD4-CD8-TCRgd+ bearing CD161 also produce IL-17 but cells of these same phenotypes and functional marker which do not bear CD161 also do not produce IL-17. Induction of CD161 expression by transduction with RORC also induces IL-1R and IL-23R as well as the ability to produce IL-17. The ability to produce IL-17 and the induction of CD161 shows a strong dependency for RORC. Antibody to CD161 provides a probe for identifying IL-17 producing cells and offers a finer delineation of additional subsets derived from Th17 and their functional characteristics through cytokine mRNA expression or production.
Synonyms	CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1; NKR-P1A; NKRP1A
Reference Data
Protein Families	Transmembrane

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.