MCP1 (CCL2) Mouse Monoclonal Antibody [Clone ID: 2D8]

Specifications

Product Data
Clone Name	2D8
Applications	ELISA, FC, ICC/IF, IHC, WB
Recommend Dilution	Western Blot: 1 - 3 ug/ml, Flow Cytometry: 1:200-1:400, Immunohistochemistry-Paraffin: 1:200-1:1000, ELISA: 1:10000, Immunohistochemistry: 1:200-1:1000, Immunocytochemistry/ Immunofluorescence: 1:200-1:1000
Reactivity	Human, Mouse, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human MCP1 expressed in E. coli. [UniProt# P13500]
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	11 kDa
Gene Name	C-C motif chemokine ligand 2
Database Link	NP_002973 Entrez Gene 20296 MouseEntrez Gene 6347 Human UniProt ID P13500
Background	This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Synonyms	GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF
Note	This MCP1 (2D8) antibody is useful for Western blot, Immunohistochemistry on paraffin-embedded sections, Immunocytochemistry/Immunofluorescence, Flow Cytometry and ELISA.
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

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