SCP3 (SYCP3) Mouse Monoclonal Antibody [Clone ID: 6F9C5]

Specifications

Product Data
Clone Name	6F9C5
Applications	ELISA, FC, ICC/IF, IHC, WB
Recommend Dilution	ELISA: 1:10000, Immunocytochemistry/ Immunofluorescence: 1:200 - 1:1000, Immunohistochemistry: 1:200 - 1:1000, Immunohistochemistry-Paraffin: 1:200 - 1:1000, Western Blot: 1:500 - 1:2000, Flow Cytometry: 1:200 - 1:400
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partial recombinant human SCP3 (between residues 1-200) expressed in E. coli [UniProt Q8IZU3]
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	synaptonemal complex protein 3
Database Link	NP_710161 Entrez Gene 50511 Human UniProt ID Q8IZU3
Background	SCP3 (Synaptonemal complex protein 3) is a DNA-binding nuclear protein that belongs to XLR/SYCP3 family and is an essential structural component of the transverse filaments of synaptonemal complexes formed between homologous chromosomes during meiotic prophase. Synaptonemal complex develops during prophase of first meiosis, wherein it allows the synapse as well as recombination between maternal - paternal chromosome, and SCP3 is essential to hold cohesin complex between homologous chromosomes, which avoid premature segregation thereby preventing aneuploidies. SCP3 is involved in phosphorylation of HORMAD1 and HORMAD2. It is essential to development of testis (where it is primarily localized) and defective SCP3 may leads to spermatogenic failure type 4 (SPGF4). SCP3 deificient mouse depicts high numbers of aneuploidies in oocytes and offspring. SCP3 is also expressed in certain malignancies including human acute lymphatic leukemias, cervical cancer cells, lung cancer cells etc.
Synonyms	COR1; SCP3; SPGF4
Reference Data

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