IL17RA Mouse Monoclonal Antibody [Clone ID: 49M4D2]

Specifications

Product Data
Clone Name	49M4D2
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry: 1:20-1:1000, Western Blot: 1:100-1:2000, Immunohistochemistry-Paraffin: 1:10-1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Within the range of amino acids 186-291 of human IL-17RA were used as the immunogen for the antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 17 receptor A
Database Link	NP_001276834 Entrez Gene 23765 Human UniProt ID Q96F46
Background	IL-17RA (IL-17 receptor A), a type I transmembrane protein with a ubiquitous cell and tissue distribution has no homology with any known cytokine receptor family. This receptor is a member of the IL-17 Receptor family. IL-17RA encodes an unusually large cytoplasmic tail and was shown to activate inflammatory events typical of innate cytokines such as TNFa and IL-1b including activation of the transcription factor NF-KappaB. IL-17RA is highly expressed on hematopoietic cells, but also at lower levels on osteoblasts, fibroblasts, endothelial cells, and epithelial cells (Chang SH, 2011) (Zhu S, 2010).>The role of the IL-17 family during parasite infections is an emerging area of research with often contradicting results. In this regard, IL-17RA signaling has been shown to be both deleterious and protective during Toxoplasma gondii infection. Furthermore, two groups demonstrated that IL-17 plays a protective role in T. cruzi infection although the underlying mechanisms remains poorly understood. Indeed, both reports showed significant contradictions that might be related to the different experimental settings but deserves further investigation and discussion, since members of the IL-17 family, IL-17A, IL-17E and IL-17F, are produced during T. cruzi infection. Furthermore, it is confirmed that IL-17RA signaling is required for host resistance during the T. cruzi infection and focused at the mechanisms underlying IL-17RA-mediated protective effect. IL-17RA antibody has the potential to be a therapeutic option for many diseases (Raychaudhuri SP, 2012) (Tosello Boari J .2012).
Synonyms	CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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