GFI1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry, Western Blot: 6-8ug/ml~, Immunohistochemistry-Paraffin: 5ug/ml
Reactivity	Human, Mouse, Rat, Bovine, Chicken
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acid 280-330 of human Zinc finger protein Gfi-1 was used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	growth factor independent 1 transcriptional repressor
Database Link	NP_005254 Entrez Gene 14581 MouseEntrez Gene 24388 RatEntrez Gene 2672 Human UniProt ID Q99684
Background	Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.
Synonyms	GFI-1; GFI1A; SCN2; ZNF163
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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