SNAIL (SNAI1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:100, Western Blot: 3-5ug/ml, Knockout Validated
Reactivity	Human, Mouse, Canine, Equine
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 80-130 of human SNAI1 was used as the immunogen
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	snail family transcriptional repressor 1
Database Link	NP_005976 Entrez Gene 20613 MouseEntrez Gene 6615 Human UniProt ID O95863
Background	Zinc finger protein SNAI1 is a zinc finger transcriptional repressor which down regulates the expression of ectodermal gene within the mesoderm and thus functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stroma is a new putative prognosis marker for colon tumors. In recent studies SNAI1 was found to be potential target for Proteasome degradation by hypoxia-controlled FBXL14 ubiquitin ligase targets.
Synonyms	dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL; SNAIL1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adherens junction

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