CRLF2 Mouse Monoclonal Antibody [Clone ID: 59N5G4]

Specifications

Product Data
Clone Name	59N5G4
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry, Western Blot: 1:100-1:2000, Immunohistochemistry-Paraffin
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Amino acids 119-231 of human TSLPR protein were used as the immunogen for the antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cytokine receptor-like factor 2
Database Link	NP_071431 Entrez Gene 64109 Human UniProt ID Q9HC73
Background	TSLPR is a member of the hematopoietin receptor family which acts as a receptor for the cytokine thymic stromal lymphopoietin (TSLP) that promotes CD4(+) T cell homeostasis and contributes to allergic and inflammatory responses. TSLPR is a heterodimeric complex, consisting of the IL-7R-alpha chain and a common gamma-like receptor chain. The protein contains two fibronectin type III-like domains, four conserved cysteine residues, and a WSXWS box-like motif at its N-terminal, while the C-terminal intracellular region contains box 1 and box 2-like motifs. The protein is usually expressed in liver, kidney, heart, and skeletal muscle. The gene for human TSLPR is localized to the pseudoautosomal region, Xp22.3 and Yp11.3.
Synonyms	CRL2; CRLF2Y; TSLPR
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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