TLR7 Mouse Monoclonal Antibody [Clone ID: 4G6]

Specifications

Product Data
Clone Name	4G6
Applications	CyTOF-ready, FC, ICC/IF, IHC, WB
Recommend Dilution	Western Blot: 10ug/ml~, Flow Cytometry: 1-2ug/10^6cells, Flow (Intracellular): 5 ug/ml, Knockout Validated, CyTOF-ready, Immunocytochemistry/ Immunofluorescence: 1:500-1:5000, Immunohistochemistry: 1:50 - 1:200, Knockdown Validated
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	A partial human TLR7 recombinant protein (amino acids 562-839) was used as the immunogen. 277 amino acid ( AA 562- 839)~
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	toll like receptor 7
Database Link	NP_057646 Entrez Gene 170743 MouseEntrez Gene 51284 Human UniProt ID Q9NYK1
Background	TLR7 is a 1049 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. It acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Synonyms	TLR7-like
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Toll-like receptor signaling pathway

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