EBI3 Mouse Monoclonal Antibody [Clone ID: 15k8D10]

Specifications

Product Data
Clone Name	15k8D10
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunohistochemistry-Paraffin: 5ug/ml, Western Blot: 3-5ug/ml~, Tissue Culture Substratum, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A full-length human Interleukin-35-Fc fusion protein was used as immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Epstein-Barr virus induced 3
Database Link	NP_005746 Entrez Gene 10148 Human UniProt ID Q14213
Background	IL-35 is a novel heterodimeric cytokine composed of the IL-12p35 subunit and the Epstein-Barr virus-induced gene 3 (EBI3) protein. As one of the IL-12 family members, IL-35 is known to play an essential role in immune regulation of the CD4+CD25+ regulatory T (Treg) cells, from which IL-35 is also specifically produced. IL-35 is able to expand CD4+CD25+ Treg cells whereas it can inhibit proliferation of CD4+CD25- effector T (Teff) cells and development of proinflammatory Th17 cells, suppressing inflammatory responses.
Synonyms	IL-27B; IL27B
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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