WHIP (WRNIP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-WRNIP1 antibody: synthetic peptide directed towards the N terminal of human WRNIP1. Synthetic peptide located within the following region: PGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPT
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	72 kDa
Gene Name	Werner helicase interacting protein 1
Database Link	NP_569079 Entrez Gene 56897 Human UniProt ID Q96S55
Background	Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects inThe Werner syndrome ATP-dependent helicase gene (WRN).The protein encoded byThis gene interacts withThe exonuclease-containing N-terminal portion ofThe Werner protein.This protein has a ubiquitin-binding zinc-finger domain inThe N-terminus, an ATPase domain, and two leucine zipper motifs inThe C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human.This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increasesThe initiation frequency of DNA polymerase delta-mediated DNA synthesis.This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated forThis gene. [provided by RefSeq, Jul 2012]
Synonyms	bA420G6.2; WHIP
Note	Immunogen Sequence Homology: Dog: 100%; Rat: 100%; Human: 100%; Mouse: 100%; Zebrafish: 85%; Pig: 79%; Bovine: 79%; Yeast: 77%
Reference Data

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