CHD3 Mouse Monoclonal Antibody [Clone ID: 7F6-G2-E5]

Specifications

Product Data
Clone Name	7F6-G2-E5
Applications	IF, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:400
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for CHD3 antibody: purified recombinant human CHD3 (C-terminus) protein fragments expressed in E.coli.
Formulation	ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	260 kDa
Gene Name	chromodomain helicase DNA binding protein 3
Database Link	NP_001005271 Entrez Gene 216848 MouseEntrez Gene 303241 RatEntrez Gene 1107 Human UniProt ID Q12873
Background	This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Synonyms	Mi-2a; Mi2-ALPHA; ZFH
Reference Data
Protein Families	Druggable Genome

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