PKM2 (PKM) Mouse Monoclonal Antibody [Clone ID: 1F2-F4-H11]

Specifications

Product Data
Clone Name	1F2-F4-H11
Applications	IF, IP, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for PKM2 antibody: purified recombinant human PKM2 protein fragments expressed in E.coli.
Formulation	PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	pyruvate kinase, muscle
Database Link	NP_002645 Entrez Gene 697742 MonkeyEntrez Gene 5315 Human UniProt ID P14618
Background	This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
Synonyms	CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glycolysis / Gluconeogenesis, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus

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