SHP1 (PTPN6) Mouse Monoclonal Antibody [Clone ID: 2B7-H7-F8]
CAT#: TA347034
Mouse Monoclonal SHP-1 Antibody
Size: 20 ul
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CNY 2,700.00
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Specifications
Product Data | |
Clone Name | 2B7-H7-F8 |
Applications | WB |
Recommend Dilution | WB: 1:1000 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | The immunogen for PTPN6 antibody: purified recombinant human SHP-1 protein fragments expressed in E.coli. |
Formulation | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol. |
Purification | Affinity purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | protein tyrosine phosphatase, non-receptor type 6 |
Database Link | |
Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
Synonyms | HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1 |
Reference Data | |
Protein Families | Druggable Genome, Phosphatase, Stem cell - Pluripotency |
Protein Pathways | Adherens junction, B cell receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway |
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