BRG1 (SMARCA4) Mouse Monoclonal Antibody [Clone ID: 4E11-E11-G11]

Specifications

Product Data
Clone Name	4E11-E11-G11
Applications	IP, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for SMARCA4 antibody: purified recombinant human BRG1 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	220 kDa
Gene Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Database Link	NP_001122316 Entrez Gene 6597 Human UniProt ID P51532
Background	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI,which is required for transcriptional activation of genes normally repressed by chromatin.In addition, this protein can bind BRCA1,as well as regulate the expression of the tumorigenic protein CD44.Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2.Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,May 2012]
Synonyms	BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; RTPS2; SNF2; SNF2L4; SNF2LB; SWI2
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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