STAT3 Mouse Monoclonal Antibody [Clone ID: 4C8-1C9-H8]

Specifications

Product Data
Clone Name	4C8-1C9-H8
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat, Hamster, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for STAT3 antibody: purified recombinant human STAT3 protein fragments expressed in E.coli
Formulation	ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	88 kDa
Gene Name	signal transducer and activator of transcription 3
Database Link	NP_644805 Entrez Gene 20848 MouseEntrez Gene 25125 RatEntrez Gene 6774 Human UniProt ID P40763
Background	The protein encoded by this gene is a member of the STAT protein family.In response to cytokines and growth factors,STAT family members are phosphorylated by the receptor associated kinases,and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs,EGF,IL5,IL6,HGF,LIF and BMP2.This protein mediates the expression of a variety of genes in response to cell stimuli,and thus plays a key role in many cellular processes such as cell growth and apoptosis.The small GTPase Rac1 has been shown to bind and regulate the activity of this protein.PIAS3 protein is a specific inhibitor of this protein.Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq,Jul 2008]
Synonyms	ADMIO; APRF; HIES
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Acute myeloid leukemia, Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer

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