USP7 Mouse Monoclonal Antibody [Clone ID: 3E4-D10-E8]

CAT#: TA347070S

Mouse Monoclonal HAUSP / USP7 Antibody

Size: 20 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 20 ul

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Recombinant protein of human ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), 20 µg
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Transient overexpression lysate of ubiquitin specific peptidase 7 (herpes virus-associated) (USP7)
    • 100 ug

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Specifications

Product Data
Clone Name 3E4-D10-E8
Applications WB
Recommend Dilution WB: 1:200
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen The immunogen for USP7 antibody: purified recombinant human HAUSP / USP7 protein fragments expressed in E.coli.
Formulation ascites
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 135 kDa
Gene Name ubiquitin specific peptidase 7 (herpes virus-associated)
Background Hydrolase that deubiquitinates target proteins such as FOXO4,p53/TP53,MDM2,ERCC6,DNMT1,UHRF1,PTEN and DAXX.Together with DAXX,prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53,thereby promoting p53/TP53 ubiquitination and proteasomal degradation.Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2,and also induces p53/TP53-dependent cell growth repression and apoptosis.Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity.In association with DAXX,is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm,both processes that are counteracted by PML.Involved in cell proliferation during early embryonic development.Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage:recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6,preventing UV-induced degradation of ERCC6.Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1:acts by mediating deubiquitination of UHRF1 and DNMT1,preventing their degradation and promoting DNA methylation by DNMT1.Exhibits a preference towards 'Lys-48'-linked Ubiquitin chains.
Synonyms HAUSP; TEF1
Reference Data
Protein Families Druggable Genome, Protease
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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