BAZ2A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ChIP (5 µl/ChIP); Western blotting (1:1,000)
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-TIP-5 antibody: TIP5 (Transcription termination factor I-interacting protein 5), using the recombinant protein.
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	bromodomain adjacent to zinc finger domain 2A
Database Link	NP_038477 Entrez Gene 116848 MouseEntrez Gene 11176 Human UniProt ID Q9UIF9
Background	TIP 5 (UniProt/Swiss-Prot entry Q9UIF9) is the large subunit of the nucleolar remodeling complex NoRC. NoRC causes the repression of ribosomal gene transcription. It was demonstrated that histone deacetylation is involved in this repression and that TIP5 is associated with the histone deacetylase HDAC1 and mediates the deacetylation of histones in the vicinity of the rDNA promoter. The interaction of TIP5 and HDAC1, which is necessary for transcriptional repression, is established by the C-terminal PHD finger and bromodomain.
Synonyms	TIP5; WALp3
Reference Data
Protein Families	Druggable Genome

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