H2A.Z (H2AFZ) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, ELISA, IF
Recommend Dilution	ChIP/ChIP-seq (1ug per ChIP); ELISA (1:500 ?? 1:200); Dot blotting (1:20,000); Immunofluoresence (1:500)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-H2A.Zac antibody: histone H2A.Z acetylated at lysines 5, 7 and 11, using a KLH-conjugated synthetic peptide.
Concentration	lot specific
Purification	Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	H2A histone family member Z
Database Link	NP_002097 Entrez Gene 3015 Human UniProt ID P0C0S5
Background	Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Acetylation of the histone H2A variant H2A.Z is associated with the promoters of active genes.
Synonyms	H2A; H2A.z; H2A.Z-1; H2AZ; z
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Systemic lupus erythematosus

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