HIRA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA (1:100 ?? 1:200) ; Western blotting (1:1,000)
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Hira antibody: mouse Hira (histone cell cycle regulation defective homolog A), using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	histone cell cycle regulator
Database Link	NP_003316 Entrez Gene 15260 Mouse UniProt ID P54198
Background	Hira (UniProtKB/Swiss-Prot entry P54198) is a histone chaperone that cooperates with ASF1A to promote replication-independent chromatin assembly. It is important for histone regulation and is required for the periodic repression of histone gene transcription during the cell cycle. Hira plays an important role in the formation of transcriptionally silent senescence-associated heterochromatic foci (SAHF). SAHF, which contain heterochromatin proteins such as HP1, are believed to repress expression of proliferation-promoting genes, leading to the irreversible cell cycle changes that occur in senescent cells. Interaction between HIRA and ASF1A is the rate limiting step in the formation of SAHF. Hira is also thought to be involved in certain haploinsufficiency syndromes such as DiGeorge syndrome. Insufficient production of Hira protein may disrupt normal embryonic development.
Synonyms	DGCR1; TUP1; TUPLE1
Reference Data
Protein Families	Transcription Factors

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