RAD17 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-RAD17 Antibody: A synthesized peptide derived from human RAD17
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Affinity-chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	77 kDa
Gene Name	RAD17 checkpoint clamp loader component
Database Link	NP_579922 Entrez Gene 19356 MouseEntrez Gene 310034 RatEntrez Gene 5884 Human UniProt ID O75943
Background	Rad17 a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. Binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. Phosphorylated and activated after DNA damage, inducing cell cycle G2 arrest. Eight alternatively spliced variants have been reported.
Synonyms	CCYC; HRAD17; R24L; RAD17SP; RAD24
Note	RAD17 antibody detects endogenous levels of total RAD17
Reference Data
Protein Families	Druggable Genome

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