E Cadherin (CDH1) Rabbit Polyclonal Antibody

CAT#: TA347355

Rabbit Polyclonal Anti-E-cadherin Antibody



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ug

Product images

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Recombinant protein of human cadherin 1, type 1, E-cadherin (epithelial) (CDH1), 20 µg
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Recombinant protein of human cadherin 1, type 1, E-cadherin (epithelial) (CDH1), 100 µg
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:500-1:3000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen The immunogen for anti-E-cadherin Antibody: A synthesized peptide derived from human E-cadherin
Formulation Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration lot specific
Purification Affinity-chromatography
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 120 kDa
Gene Name cadherin 1
Background CDH1 a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis.
Synonyms Arc-1; CD324; CDHE; ECAD; LCAM; UVO
Note E-cadherin antibody detects endogenous levels of total E-cadherin
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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