SIRP alpha (SIRPA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-SHPS1 Antibody: A synthesized peptide derived from human SHPS1
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Affinity-chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55 kDa
Gene Name	signal regulatory protein alpha
Database Link	NP_542970 Entrez Gene 19261 MouseEntrez Gene 25528 RatEntrez Gene 140885 Human UniProt ID P78324
Background	SHPS1 Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
Synonyms	BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP
Note	SHPS1 antibody detects endogenous levels of total SHPS1
Reference Data
Protein Families	Druggable Genome, Phosphatase, Transmembrane

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