BRG1 (SMARCA4) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Brg1 Antibody: Peptide sequence around aa.701~705(V-D-A-R-H) derived from Human Brg1.
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	185,200kd
Gene Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Database Link	NP_001122321 Entrez Gene 20586 MouseEntrez Gene 171379 RatEntrez Gene 6597 Human UniProt ID P51532
Background	Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex
Synonyms	BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; RTPS2; SNF2; SNF2L4; SNF2LB; SWI2
Note	The antibody detects endogenous level of total Brg1 protein.
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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