CYP26A1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	IF
Recommend Dilution	IHC: 4-6 ug/ml
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	The immunogen for Anti-CYP26A1 Antibody: Peptide with sequence C-NLPARFTHFHGE, from the internal region of the protein sequence according to NP_000774.2; NP_476498.1.
Formulation	Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cytochrome P450 family 26 subfamily A member 1
Database Link	NP_000774 Entrez Gene 1592 Human UniProt ID O43174
Background	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Synonyms	CP26; CYP26; P450RAI; P450RAI1
Note	This antibody is expected to recognize both reported isoforms (NP_000774.2; NP_476498.1)
Reference Data
Protein Families	Druggable Genome, P450, Transmembrane
Protein Pathways	Retinol metabolism

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