Cideb Rabbit Polyclonal Antibody

Specifications

Product Data
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	CIDE-B antibody was raised against a 16 amino acid peptide near the carboxy terminus of murine CIDE-B.
Formulation	PBS containing 0.02% sodium azide.
Purification	CIDE-B Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
Database Link	AF041377 Entrez Gene 12684 Mouse UniProt ID O70303
Background	CIDE-B Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes, and bone marrow.
Synonyms	CIDEB
Reference Data

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