OLIG2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	OLIG2 antibody was raised against a 15 amino acid peptide near the amino terminus of human OLIG2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	OLIG2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 36 kDa; Observed: 37 kDa
Gene Name	oligodendrocyte lineage transcription factor 2
Database Link	NP_005797 Entrez Gene 50913 MouseEntrez Gene 304103 RatEntrez Gene 10215 Human UniProt ID Q13516
Background	The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1). Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2). OLIG2 is first observed in the ventral most p3 progenitor domain of the ventral neural tube while OLIG1 is first expressed in the dorsal portion of the p3 domain (2). Mice overexpressing OLIG2 exhibit impaired potassium channel expression in neural progenitors and proliferation of these cells similar to that seen in Down Syndrome, suggesting that OLIG2 may play a role in this pathology (3).
Synonyms	BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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