SREBP1 (SREBF1) Rabbit Polyclonal Antibody

CAT#: TA349059

Rabbit Polyclonal Anti-SREBF1 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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经常一起买 (2)
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Transient overexpression lysate of Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)
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Specifications

Product Data
Applications IF, IHC
Recommend Dilution WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen SREBF1 antibody was raised against a 17 amino acid peptide near the center of human SREBF1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification SREBF1 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 129 kDa; Observed: 132 kDa
Gene Name sterol regulatory element binding transcription factor 1
Background The sterol regulatory element binding transcription factor 1 (SREBF1) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1). The related protein SREBF2 also binds SRE1 and activates transcription in an additive fashion to SREBF1 (2). SREBF1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1 (3). The SREBF1 proteins are important in the regulation of genes involved in lipid metabolism, while SREBF2 has been more closely associated with cholesterol synthesis and accumulation (4).
Synonyms SPI-B
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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