SREBP2 (SREBF2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	SREBF2 antibody was raised against a 15 amino acid peptide near the center of human SREBF2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SREBF2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 126 kDa; Observed: 128 kDa
Gene Name	sterol regulatory element binding transcription factor 2
Database Link	NP_004590 Entrez Gene 6721 Human UniProt ID Q12772
Background	The sterol regulatory element binding transcription factor 2 (SREBF2) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1,2). The related protein SREBF1 also binds SRE1 and activates transcription in an additive fashion to SREBF2 (2). SREBF2 has been more closely associated with cholesterol synthesis and accumulation, while the SREBF1 proteins are important in the regulation of genes involved in lipid metabolism (3).
Synonyms	bHLHd1; SREBP-1c; SREBP1; SREBP1a
Reference Data

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