Mitofusin 1 (MFN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	MFN1 antibody was raised against a 17 amino acid peptide near the amino terminus of human MFN1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	MFN1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 82 kDa; Observed: 83 kDa
Gene Name	mitofusin 1
Database Link	NP_284941 Entrez Gene 67414 MouseEntrez Gene 192647 RatEntrez Gene 55669 Human UniProt ID Q8IWA4
Background	Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3). When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4).
Synonyms	hfzo1; hfzo2
Reference Data

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