Parkin (PARK2) Rabbit Polyclonal Antibody

CAT#: TA349075

Rabbit Polyclonal Anti-PARK2 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommend Dilution PARK2 antibody can be used for detection of PARK2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen PARK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human PARK2
Specificity PARK2 antibody is human specific.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification PARK2 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 51 kDa; Observed: 55 kDa
Gene Name parkin RBR E3 ubiquitin protein ligase
Background Parkinson’s disease (PD) is a neurodegenerative disease whose symptoms include tremors, rigidity, bradykinesia, and postural instability (1). Mutations in the PARK2 gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease (2). The PARK2 protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation (3). Recent studies have suggested that PARK2 expression reduces the mitochondrial accumulation of the apoptosis protein Bax under basal conditions and directly ubiquitinates Bax, thereby promoting cell survival (4).
Synonyms DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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