TXNIP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP. The immunogen is located within amino acids 110 - 160 of TXNIP.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TXNIP antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 43 kDa; Observed: 39 kDa
Gene Name	thioredoxin interacting protein
Database Link	NP_006463 Entrez Gene 10628 Human UniProt ID Q9H3M7
Background	Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).
Synonyms	HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6
Reference Data

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