PI 3 Kinase regulatory subunit 4 (PIK3R4) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PIK3R4 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PIK3R4.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	PIK3R4 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 149 kDa; Observed: 140 kDa
Gene Name	phosphoinositide-3-kinase regulatory subunit 4
Database Link	NP_055417 Entrez Gene 30849 Human UniProt ID Q99570
Background	PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4, also known as VPS15) is a 150kD adaptor protein that enhances the lipid kinase activity of PIK3 complexes and may be involved in regulating membrane trafficking late in the endocytic pathway and autophagy (1,2). PIK3R4 is ubiquitously expressed and contains 7 WD repeats, 3 HEAT repeats and 1 protein kinase domain (1). PIK3R4 is crucial for VPS34 function and is necessary for autophagosome formation in multicellular animals and reveal an important role of VPS15 in cellular protection against ubiquitin-positive protein aggregates (3-5).
Synonyms	SCCD; TERE1
Reference Data

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